Seed and pulp extract.
This section is a list of chemical entities identified in this dietary supplement to possess pharmacological activity. This list does not imply that other, yet unidentified, constituents do not influence the pharmacological activity of this dietary supplement nor does it imply that any one constituent possesses greater influence on the overall pharmacological effect of this dietary supplement.
Diphenol hydroxybenzene complex (triclosan).(1
Uses of grapefruit seed extract in various industries include: agriculture (bactericide in both pre-harvest and post-harvest treatment); fish and poultry industry (disinfectant for fresh fish and poultry); also preservative for these processed foods; animal feed industry (mold inhibitor and antiparasitic); food industry (preservative and antioxidant); cosmetic industry (preservative and antimicrobial); water treatment (disinfectant for contaminated water); as a disinfectant in hospitals and healthcare facilities; and in the dietary supplement industry (as antifungal, antibacterial, helps restore bowel health).
100mg, 1-3 times a day with meals.
Liquid: 5-10 drops, 2-3 times a day with meals.
Oral rinse: 5-10 drops in water, 2-3 times a day, swish and expectorate.
100mg, 3 times a day with meals.
Liquid: 5 drops, 3 times a day with meals.
Oral rinse: 5 drops in water, 3 times a day, swish and expectorate.
*Standardization represents the complete body of information and controls that serve to enhance the batch to batch consistency of a botanical product, including but not limited to the presence of a marker compound at a defined level or within a defined range.
Frequently Reported UsesOther Reported Uses
Grapefruit seed extract is safe in recommended dosages.
If allergy develops, discontinue use.
If diarrhea develops, discontinue use.
Use in pregnancy has not yet been determined.
Grapefruit seed extract has been reported to be a broad-spectrum antimicrobial both in vitro
and in vivo
. Studies indicate that the antimicrobial activity of grapefruit seed extract exists in the cytoplasmic membrane of the invading bacteria, where the uptake of amino acids is prevented. There is disorganization of the cytoplasmic membrane and leakage of low molecular weight cellular contents, ultimately resulting in inhibition of cellular respiration and death.(2
Grapefruit seed extract also inhibits the growth of H. pylori and C. jejuni, both causative agents in gastrointestinal ulcers.(3) Not only does grapefruit seed extract aid in decreasing gastrointestinal ulceration, it also inhibits Candida overgrowth, which is a major concern in bowel health and maintaining normal bacterial flora of the GIT.(4) In one human study in individuals with gastrointestinal permeability due to bowel flora imbalance, an improvement in constipation, flatulence, abdominal distress, and night rest were noticed after four weeks of therapy. Most clinicians now agree on the importance of maintaining homeostasis of the microflora in health and disease.(5)
A recent study was performed to determine the antimicrobial efficacy as well as the content of preservative agents of six commercially available grapefruit seed extracts in Europe.(6) Synthetic preservative agents were found to be contained within the effective products. The product with no synthetic preservative did not appear to have any antimicrobial activity.
Grapefruit seed extract is not reported to contain naringin, the constituent in grapefruit juice that may alter the metabolism of certain medications.(7) However, until further research is performed, use grapefruit seed extract with caution in individuals on medications metabolized by the CYP34A pathway, including terfenadine, astemizole, cisapride, "statin" hypocholesterolemics, saquinavir, cyclosporin, midazolam, triazolam, verapamil, and warfarin among others.(8)